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O4‐02‐05: Neuropathologic basis of white matter hyperintensity accumulation
Author(s) -
ErtenLyons Deniz,
Woltjer Randy,
Dodge Hiroko,
Stanfield Sarah,
Reese Lindsay,
Tran Huong,
Quinn Joseph,
Wild Kathryn,
Oken Barry,
Kaye Jeffrey,
Silbert Lisa
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1644
Subject(s) - pallor , hyperintensity , arteriosclerosis , autopsy , medicine , cardiology , white matter , magnetic resonance imaging , pathology , myelin , radiology , central nervous system
cohort ranging from cognitively-normal elderly (NC) to Alzheimer’s Disease dementia (AD), over 3 years. Methods: 174 participants were studied at entry from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) with 3T SWI MRI and 11C-PiB PET. 120 (79 NC, 23 with Mild Cognitive Impairment (MCI) and 18 AD) returned for imaging at 18 months or 3 years. Images were inspected for microbleeds and infarction, blind to clinical and PiB findings. White matter hyperintensity (WMH) volume was quantified from FLAIR images using a semi-automated algorithm. PiB binding was treated as both a continuous variable (SUVR) and dichotomized as previously published (PiB+/-). All regression analyses were adjusted for age and gender. Results: LMB were present at baseline in 28% of NC, 34% of MCI and 44% of AD patients. The prevalence was 53% in PiB+ NC and 16% in PiBNC. The mean incidence rate of LMB was significantly different between NC (0.18 LMB/year), MCI (0.28) and AD (1.04 LMB/year). In NC, it was 0.38 for PiB+ and 0.09 for PiB(P<0.01). Baseline LMB were associated with age (OR 1.1, 95% C.I.1.01.2) and SUVR (OR 4.8, 95% C.I.1.5-14.8) in NC participants, and with SUVR (OR 3.6, 95% C.I.1.2-10.3), male gender (OR 7.9, 95% C.I.2.328.1) and WMH volume (OR 1.1, 95%C.I. 1.0-1.1) in MCI and AD. For NC, LMB incidence rate was associated with SUVR and the presence of baseline lacunes, while for AD and MCI patients, LMB incidence was associated with WMH volume and of baseline lacunes. Conclusions: Incidence of lobarmicrobleeds is associated with Ab-burden andmarkers of small vessel disease.