Premium
IC‐P‐121: Disrupted functional integrity between task‐positive and task‐negative networks in the early stages of Alzheimer's disease
Author(s) -
Wang Zhiqun,
Xia Mingrui,
Lin Qixiang,
He Yong,
Li Kuncheng
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.155
Subject(s) - neuroscience , prefrontal cortex , default mode network , posterior cingulate , resting state fmri , middle frontal gyrus , inferior frontal gyrus , psychology , fusiform gyrus , middle temporal gyrus , gyrus , anterior cingulate cortex , voxel , superior frontal gyrus , medial frontal gyrus , task positive network , cortex (anatomy) , medicine , functional connectivity , functional magnetic resonance imaging , cognition , radiology
Relationship to clinical diagnosis was examined using a Receiver Operator Characteristic approach, including age, gender, education and ApoE4 as covariates.Results: Four significant components were identified for FDG (see Figure). These included a left inferior frontal and temporal component correlated with lvPPA (AUC 0.90, P 1⁄4 0.009), a bilateral inferior frontal (low metabolism) and PCC/precuneus (high metabolism) component correlated with ADmem (0.83, P 1⁄4 0.039) and two others correlated with PCA (bilateral occipito-temporal (0.88, P 1⁄4 0.012) and right PCC/lateral parietal (0.78, P 1⁄4 0.05)). None of the 4 significant PIB components (left PCC/lateral parietal, right parieto-temporal, bilateral inferior frontal, bilateral PCC/ precuneus) correlated with diagnosis. A significant mixed FDG-PIB coefficient was found in which decreased frontal and increased PCC/precuneus FDG uptake was correlated with the inverse pattern (increased frontal, decreased PCC/precuneus) of PIB uptake (partial r 1⁄4 0.76, P <0.0001). Conclusions: In conclusion, we found that three clinical phenotypes of AD (ADmem, PCA, LPA) correlated with independent components of FDG but not with PIB. PIB and FDG showed inverse relationships in frontal cortex and PCC/precuneus. Altogether, parallel ICA may help better understand the relationships between clinical phenotype, glucose metabolism and amyloid.