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P3‐266: Verbal fluency in multiple categories in mild cognitive impairment (MCI)
Author(s) -
Forlenza Orestes,
Mirandez Roberta,
Radanovic Márcia
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1489
Subject(s) - fluency , verbal fluency test , logistic regression , dementia , psychology , audiology , cognition , clinical psychology , cognitive impairment , receiver operating characteristic , medicine , disease , psychiatry , neuropsychology , mathematics education
utive domains, without any memory subtest to avoid circularity. IIVwas calculated following two different methods : (1) a variability score for each subtest, and (2) a “cognitive asymmetry” score that corresponds to the variability between two targeted cognitive domains (verbal / spatial, executive / spatial, within-verbal and within-spatial domains).Results: The 4 pAD participants were impaired for only 2 subtests of the battery. By contrast, the first variability measure method yielded an IIV more than two times higher in pAD. Further, “cognitive asymmetries” method led by far to the largest significant differences between each pAD participants and controls, still with more variability in pAD patients. Conclusions: Despite broadly normal cognitive performances in single tests, pADmay be predicted on the basis of abnormal IIV. Moreover, our data highlights the sensitivity of cognitive asymmetries measures to pAD, which correspond to cognitive discrepancies between domains that involve distinct brain regions. Therefore, we discuss our data in terms of an inability of the pAD brain to carry out interand intra-hemispheric compensation processes usually observed in healthy aging.