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P3‐258: Profiles of functional and cognitive impairment in Alzheimer's disease and mild cognitive impairment compared to elderly community controls
Author(s) -
Marsico Mark,
Jager Celeste,
Zhu Xingshu,
Markwick Arwen,
Chandler Julie
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1481
Subject(s) - cognition , psychology , cognitive impairment , audiology , effects of sleep deprivation on cognitive performance , alzheimer's disease , cognitive test , dementia , cohort , disease , medicine , psychiatry
Gender and number of APOE e 4 alleles included as covariates. Results: We tested a total of 11 SNPs and the APOE e 4 allele for association with AD in our African American case control series (106 AD, 208 controls). None of the SNPs tested achieved nominally significant association with AD diagnosis. Analysis of APOE identified significant increased risk with increasing number of APOE e 4 alleles (OR1⁄43.92, p<1e-04).Conclusions: The novel LOAD susceptibility loci identified in recent years through GWAS analysis of Caucasian LOAD patients and controls do not achieve nominally significant association in our African American case control series. This may be due to the small sample size of our case control series, resulting in the study being underpowered, or may reflect a true fundamental difference in the association of these SNP’s with AD in the two populations. Analysis with cognitive quantitative phenotypes collected in these subjects will be carried out. To increase the power of these studies, recruitment/collection of biological samples of AD patients and controls in the African American population is of increasing importance.