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P3‐254: Reliability and validity of the Chinese NTB
Author(s) -
Yuanyuan Liu,
Xiao Fu
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1477
Subject(s) - cronbach's alpha , statistics , pearson product moment correlation coefficient , mathematics , reliability (semiconductor) , psychology , correlation , audiology , psychometrics , medicine , power (physics) , physics , geometry , quantum mechanics
Background: To assess the reliability and validity of the Chinese version of neuropsychological test battery (NTB). To explore the value of NTB in the diagnosis of mild cognitive impairment. Methods: 1. Mini-mental state examination (MMSE), Alzheimer’s disease assessment scale-cognitive (ADAS-cog) and NTB were administered to 129 subjects. Among of them, 29 were retested after four weeks. The internal consistency reliability and test-retest reliability were evaluated. The criterion related validity was evaluated via the correlation between NTB scores and MMSE, ADAS-cog. 2. To compare t he mean total scores of MMSE, ADAS-cog and NTB between MCI and control groups. We used discriminant analysis to select the subtests of NTB which entered into the standardized canonical discriminant functions. Then receive operating characteristic curve (ROC) was used to analyse the areas under the curve (AUCs) of NTB and subtests to discriminate MCI fromNC.Results: TheCronbach6 coefficients of NTBwas 0.828. The testretest coefficients ranged from 0.590 to 0.856 (P<0.001). The Pearson’s correlation coefficient among theNTB subtests andNTB total score ranged from 0.693 to 0.872, and 0.297 to 0.848 of the NTB subtests. Principal axis factoring analysis of NTB yielded two factors which contributed to 71.198% of the cumulative variance. Significant correlations were found between NTB total score and MMSE, ADAS-cog, and the Pearson’s correlation coeficient were 0.874 and -0.799. 2 T here were significant differences between the two groups in t he mean total scores of MMSE, ADAS-cog and NTB. The results ofNTB tests demonstrated that therewere significant differences between the two groups in seven of the subtests at 0.01 levels. Among the significant variables, RAVLT-I and WMVer-D finally entered into the standardized canonical discriminant functions. The sensitivity of NTB in discriminating MCI was 80.0% and the speciality was 77.8%. The AUCs of NTB total score, RAVLT-I score and RAVLT-D to discriminate MCI from NC were 0.877, 0.833 and 0.818.Conclusions: 1.The NTB demonstrates good psychometric properties and meets with psychometric demand. 2. RAVLT-I, RAVLT-D and WMVer-D can discriminate MCI from normal controls and thus are sensitive tools in early detection of Alzheimer disease.