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P3‐242: Effect of age on spatial navigation
Author(s) -
Gazova Ivana,
Literáková Eva,
Hyncicova Eva,
Mokrišová Ivana,
Nedelská Zuzana,
Laczó Jan,
Hort Jakub
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1464
Subject(s) - spatial memory , morris water navigation task , spatial learning , psychology , cognition , spatial cognition , cognitive impairment , audiology , water maze , hippocampus , ageing , cognitive aging , medicine , neuroscience , working memory
Methods: From April 2007 to June 2011, in the neurology department of Seoul National University Bundang Hospital, patients diagnosed as probable Alzheimer’s disease according to NINDS-ADRDA were included. And those with extreme cognitive impairment (CDR 2, 3) were excluded. The Geriatric depression scale was used as a symptom checklist to diagnose depression. And Korean Neuropsychiatric Inventory (NPI) and Seoul-Instrumental Activities of Daily Living (SIADL) score were assessed. Results: Among 229 patients with probable Alzheimer’s disease, 127 patients (54.46%) were female. There were no differences in CDR, CDRSOB, underlying disease such as hypertension, stroke between two groups. Education years, age, total MMSE score, and diabetes were higher in the male group. The Chi-square test and independent t-test were used to check the significance of association. Geriatric depression scale was higher in female patients, but it was not significant (13.67 vs 12.54, P1⁄4.291). But depression in NPI was higher in female patients (64% vs. 36%, P1⁄4.015). The current and possible SIADL total scores were lower in female patients (13.14 vs. 16.40, P1⁄4.013), (11.79 vs 15.10, P1⁄4.009).Conclusions: There is a higher tendency of depression among patients of Alzheimer’s disease, particularly female patients. And daily performance was relatively better in female patients. We suggested that social-living status and previous daily activity were related to these results.