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P3‐236: The validity and reliability of the Korean version of Florida Facial Affect Battery
Author(s) -
Kim E.J.,
Oh JiHyang,
Ahn BoYoung,
Jo MinKyung,
Yoon YeoJo,
Kim Go Woon,
Na Duk L.
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1458
Subject(s) - affect (linguistics) , psychology , surprise , facial expression , cognition , anger , audiology , reliability (semiconductor) , clinical psychology , developmental psychology , social psychology , medicine , psychiatry , communication , power (physics) , physics , quantum mechanics
showed that by accounting for DDPTE, we were able to show a treatment effect in two previously failed trials. Results: By accounting for DDPTE, we integrated biomarker measurements obtained from patients who spanned from cognitively normal to those with moderate AD (Figure 1) and can see the hallmarks of the Jack model. In Table 1, we found that log transforming the data and applying DDPTE allowed us to see a treatment effect in the historical data fromMCI galantamine trials where no treatment effect had previously been detected. Conclusions: We proposed the estimation of a covariate for disease duration prior to trial entry, and showed the utility of this factor in both naturalistic and clinical trials. Because this method addresses the previously latent covariate of disease-duration in a novel manner, the resultant reduction of noise and variability improves potential trend detection and effect sizes. Finally, to our knowledge, this is the first empirical confirmation of the Jack model of biomarker changes in AD.