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IC‐P‐107: Whither the hippocampus?: FDG‐PET hippocampal hypometabolism in Alzheimer's disease revisited
Author(s) -
Whitlow Christopher,
Maldjian Joseph
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.141
Subject(s) - hippocampal formation , statistical parametric mapping , neuroscience , posterior cingulate , hippocampus , alzheimer's disease , neuroimaging , psychology , medicine , pathology , cortex (anatomy) , magnetic resonance imaging , disease , radiology
EBM2 BACKGROUND AND PURPOSE: The hippocampus is a widely recognized area of early change in AD, yet voxelwise analyses of FDG-PET activity differences between AD and CN controls have consistently failed to identify hippocampal hypometabolism. In this article, we propose a high-dimensional PETspecific analysis framework to determine whether important hippocampal metabolic FDG-PET activity differences between patients with AD and CN subjects are embedded in the Jacobian information generated during spatial normalization.