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P3‐189: Training‐related changes in patients with mild cognitive impairment: An fMRI study
Author(s) -
Machts Judith,
Bittner Daniel
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1409
Subject(s) - cognitive training , cognition , neuropsychology , intervention (counseling) , psychology , dementia , memory impairment , physical medicine and rehabilitation , cognitive impairment , audiology , cognitive psychology , medicine , neuroscience , psychiatry , disease
Depression-aMCI interactive effects were associated with global GM volume loss involving cortical and MTL structures (P <0.05 FDR corrected; Figure 1). Depressive symptoms were negatively correlated and episodic memory performances were positively associated with GMV in similar brain regions as observed with LLD and aMCI respectively. Depressive symptoms, memory deficit interactive effects, were also seen globally, especially in the DMNandMTL regions.Conclusions:The interactive effects of LLD and aMCI are associated with GMV loss in crucial cognition andmood regulation structures. The co-existence of these clinical phenotypes may be a marker of AD.