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P3‐179: Age‐related memory decline is mediated by processing speed and myelin integrity
Author(s) -
Lu PoHaong,
Lee Grace,
Heydari Panthea,
Couvrette Alexander,
Meghpara Michael,
Mintz Jim,
Thompson Paul,
Bartzokis George
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1399
Subject(s) - white matter , fractional anisotropy , cognitive decline , corpus callosum , splenium , neuroscience , psychology , myelin , diffusion mri , episodic memory , population , cognition , medicine , disease , magnetic resonance imaging , central nervous system , dementia , environmental health , radiology
ated with slowing in CPS, reduced white matter integrity, and higher risk of conversion toMCI. These findings suggest that depressionmay reflect underlying pathological changes in white matter that may also be associated with prodromal AD. Thus, assessment of depressive symptomsmay be a potentially useful clinical marker in identifying at-risk individuals who are most likely to progress to AD.