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P3‐174: Can we further divide amnestic mild cognitive impairment based on the pattern of memory deficit?
Author(s) -
Jeong Eun Hye,
Kim Heeyoung,
Lee JaeHong
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1394
Subject(s) - cognitive deficit , neuropsychology , audiology , hyperintensity , dementia , memory impairment , psychology , atrophy , medicine , cognition , cognitive impairment , cardiology , neuroscience , magnetic resonance imaging , disease , radiology
Background: Mild cognitive impairment (MCI) is considered as a transitional state between normal aging and dementia and can be subdivided into amnestic vs. nonamnestic and single vs. multiple domains types. It is suggested that these clinical subtypes may have different underlying etiologies and outcomes. The amnestic MCI differs in the performance profile on memory testing: retention vs. retrieval deficit. Generally, the retention deficit is attributed to the medial temporal dysfunction and the retrieval deficit to the frontal dysfunction. We tried to determine whether there could be distinctive subtypes available even in the amnestic MCI. Methods: Sixty-two patients with amnestic MCI-single domain were included in this retrospective study. They were divided into the retentionvs. the retrieval-deficit groups according to the results of Seoul Verbal Learning Test (SVLT). We compared baseline characteristics including vascular risk factors and neuropsychological profiles. We also measured the medial temporal atrophy (MTA) using a visual rating scale and assessed lacunar infarcts and white matter hyperintensities (WMH). Results: Of 62 patients, 41 had retention deficit and 21 had retrieval deficit on SVLT. Among baseline clinical and demographic variables, only the frequency of hypertension was higher in the retrieval-deficit group (P 1⁄40.005). There were no differences in neuropsychological profiles between the two groups other than a lower immediate recall score in the retention-deficit group (P1⁄40.012) and a higher recognition score in the retrieval-deficit group (P1⁄40.001). Severities ofWMHandMTA were not different between the two groups, nor were the number of lacunar infarcts and microbleeds. Conclusions: We could not find any significant difference except for the frequency of hypertension between the two subgroups of amnesticMCI, suggesting that there may be no further gain in subdividing a single domain amnestic MCI. Table Factor loadings for each ROI from analyses performed on group 1 (cognitively normal subjects) and group 2 (intermediate PIB subjects). Loadings above 0.5 are bolded for emphasis