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P3‐166: Relationships between hippocampal shape and cognitive performance in drug‐naive patients with Alzheimer's disease
Author(s) -
Lee Chung Tai,
Lee Sung Pil,
Han SangIck,
Lim HyunKook,
Seo HoJun,
Jeong JongHyun,
Hong SeongChul,
Han JinHee
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1386
Subject(s) - subiculum , hippocampal formation , recall , hippocampus , cognition , neuroscience , psychology , episodic memory , alzheimer's disease , effects of sleep deprivation on cognitive performance , medicine , audiology , disease , cognitive psychology , dentate gyrus
P1⁄40.01 right), dorsolateral prefrontal cortex (P1⁄40.0007 left; P1⁄40.002 right), left posterior cingulate (P1⁄40.02) and the right putamen (P1⁄40.02). Further adjustment for stroke, hypertension, and MI produced similar results. Conclusions: Diabetes is associated with smaller GM volume, total brain volume, greater atrophy. Micro-structural measures revealed reduced FA for total WM and greater MD in regions associated with memory and executive function, in particular in the hippocampus and dorsolateral prefrontal cortex. Further studies are needed to determine if these structural changes associated with diabetes predict risk of cognitive decline.