Premium
P3‐160: Confrontation naming deficits are associated with amyloidosis in early MCI and with synaptic dysfunction in late MCI and Alzheimer's disease: An [18F]AV45/[18F]FDG‐PET study
Author(s) -
Leuzy Antoine,
Rowley Jared,
Mohades Sara,
Dauar Marina,
Wu Liyong,
Gauthier Serge,
RosaNeto Pedro
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1380
Subject(s) - boston naming test , neuropsychology , amyloidosis , medicine , psychology , cognitive impairment , neuropsychological assessment , temporal lobe , audiology , voxel , nuclear medicine , alzheimer's disease , cognition , disease , neuroscience , radiology , epilepsy
microstructure 4. Of specific interest in this study is the extra-axonal radial diffusivity (i.e., De,t), an index of myelin integrity. Regions of interest (ROI’s) in the genu, body, and splenium of the CC were drawn based on a standardWM atlas, and their parameter values were correlated with neuropsychological measures of CPS (i.e., WAIS Digit-Symbol Coding [DSC] and Trails A). Results: Strong correlations were obtained between De,t in the three ROI’s and WAIS-DSC (gCC r 1⁄4-0.70, P<0.05; bCC r 1⁄4-0.82, P<0.01; sCC r 1⁄4-0.58, P1⁄40.08) and Trails A (gCC r 1⁄40.68, P<0.05; bCC r1⁄40.65,P<0.05; sCC r1⁄40.44, ns) in theMCI group, whereas correlations between these variables in the NC and AD groups were non-significant.Conclusions:This is the first demonstration of a strong clinical correlation between DKI-derived WM microstructural metrics and neuropsychological function.While these results are preliminary and limited by its cross-sectional design, scatterplots of these associations suggest that CPS decline in MCI via myelin degeneration may serve as a biomarker of incipient AD. Confirmation of these findings through larger longitudinal studies and in other regions involved in AD is needed.