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P3‐159: Predicting Alzheimer's‐related cognitive decline with correlational network changes
Author(s) -
Reid Andrew,
Khundrakpam Budhachandra,
Evans Alan
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1379
Subject(s) - precuneus , abnormality , neuropathology , posterior cingulate , neuroscience , psychology , temporal lobe , cognition , atrophy , neuroimaging , cognitive decline , dementia , disease , medicine , pathology , psychiatry , epilepsy
microstructure 4. Of specific interest in this study is the extra-axonal radial diffusivity (i.e., De,t), an index of myelin integrity. Regions of interest (ROI’s) in the genu, body, and splenium of the CC were drawn based on a standardWM atlas, and their parameter values were correlated with neuropsychological measures of CPS (i.e., WAIS Digit-Symbol Coding [DSC] and Trails A). Results: Strong correlations were obtained between De,t in the three ROI’s and WAIS-DSC (gCC r 1⁄4-0.70, P<0.05; bCC r 1⁄4-0.82, P<0.01; sCC r 1⁄4-0.58, P1⁄40.08) and Trails A (gCC r 1⁄40.68, P<0.05; bCC r1⁄40.65,P<0.05; sCC r1⁄40.44, ns) in theMCI group, whereas correlations between these variables in the NC and AD groups were non-significant.Conclusions:This is the first demonstration of a strong clinical correlation between DKI-derived WM microstructural metrics and neuropsychological function.While these results are preliminary and limited by its cross-sectional design, scatterplots of these associations suggest that CPS decline in MCI via myelin degeneration may serve as a biomarker of incipient AD. Confirmation of these findings through larger longitudinal studies and in other regions involved in AD is needed.