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P3‐126: Metabolic syndrome and cognitive decline in Alzheimer's disease
Author(s) -
Watts Amber,
Johnson David,
Luskatova Natalia,
Vidoni Eric,
Burns Jeffrey
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1346
Subject(s) - waist , metabolic syndrome , medicine , blood pressure , cognitive decline , dementia , cognition , body mass index , risk factor , structural equation modeling , diabetes mellitus , disease , demography , endocrinology , obesity , psychiatry , mathematics , sociology , statistics
pared to 158 age and gender matched controls by HPLC. Results: Blood vitamin C and ß-carotene concentrations in blood were statistically significant lower in demented than in control persons even after adjustment for education, intake of dietary supplements, smoking habits, body mass index and alcohol consumption (3rd vs. 1st tertile: OR: 0.29, 95%CI, 0.09-0.96 and 0.13, 95%CI, 0.03-0.55, respectively). No associations were found for vitamin E, lycopene and coenzyme Q10. Conclusions: This study suggests an association of vitamin C and ß-carotene level in blood and dementia. However this is limited to the cross-sectional character of our study and longitudinal data will give further insight in this association.