Premium
P3‐123: Evaluation of the etiology and progression of Alzheimer's disease utilizing transgenic mice fed a high fat diet
Author(s) -
Herculano Bruno,
Tamura Minami,
Ohba Ayaka,
Shimatani Mayu,
Kutsutsumaro,
Hisatsune Tatsuhiro
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1343
Subject(s) - cognitive decline , dementia , medicine , endocrinology , obesity , disease , metabolic syndrome , genetically modified mouse , hippocampal formation , physiology , transgene , biology , gene , biochemistry
for dementia by telephone, every 3-4 years. Men identified with suspected dementia by the screening protocol then completed an in-person comprehensive evaluation for dementia. Of the 7469 men in the sample, 292 developed dementia (mean onset 1⁄4 73.7). The sample included 131 twin pairs who were discordant for either dementia or for age of onset of dementia. We used proportional hazards models to investigate the association between non-work and work-related physical activity and risk of dementia. We defined our reference group as men with moderate to strenuously physical jobs, but with minimal physical exercise outside of work. Results: Compared to the reference group and controlling for education, men who had minimally physically active jobs, but had at least moderate levels of physical exercise outside of work had the lowest risk of dementia (HR1⁄40.50; CI: 0.33-0.76). Those men with both high levels of physical activity at work and non-work related exercise also had a reduced risk of dementia (HR1⁄40.61; CI: 0.44-0.84). We found a similar pattern of results when using conditional regression models to analyze only the discordant twin pairs. These latter analyses have the added benefit of controlling for many yet to be identified genetic and childhood environmental factors that may also influence the risk of dementia, but that are shared by the members of the twin pair. Conclusions: These findings indicate that all physical activity may not be equal when it comes to risk of dementia. In particular, physical exercise outside of work is more likely to be aerobic, and it also may be a marker for a generally healthier lifestyle which may contribute to preserving cognition in later life.