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IC‐P‐100: Effect of the APOE‐ɛ4 allele on longitudinal changes in cortical thickness in normal aging
Author(s) -
Madhyastha Tara,
Borghesani Paul,
Aylward Elizabeth,
Cherrier Monique,
Askren Mary,
Grabowski Thomas,
Schaie K. Warner,
Willis Sherry
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.133
Subject(s) - apolipoprotein e , medicine , alzheimer's disease neuroimaging initiative , longitudinal study , cohort , psychology , alzheimer's disease , pathology , disease
gions of interest were applied to volumetric T1-weighted MRI, FDG and PIB data. For each modality and cohort, a linear regression analysis was used to determine the effects of TDO on a vertex-by-vertex basis. Results:Differences in PIB binding between carriers (M+) and non-carriers (M-) start to diverge many years prior to symptom onset (conversion to CDR 0.5). PIB retention in non-demented carriers were significantly different from the non-carrier cohort in the caudate, putamen and thalamus and in every cortical grey matter region (Figure 1). The first areas of significant amyloid deposition include the caudate, the occipital lobe, and the frontal lobe. Significant findings for grey matter volumes, cortical thickness, and FDG were limited to those carriers with dementia (CDR > 1⁄4 0.5) and did not reach significance in the pre-symptomatic population. Conclusions: DIAN represents the largest cohort of families with ADAD studied to date. Similar to findings in sporadic AD, elevated PIB retention precedes detectable atrophy and metabolic changes by decades. Unlike sporadic AD, there is particular involvement of the caudate, and occipital lobe/visual cortex.Figure 1: Lateral surface projection of cluster corrected p-values from linear regressions for PIB, FDG, and cortical thickness, when differences first appear. With PIB, non-demented carriers (CDR0M+) demonstrate widespread amyloid deposition (left). With FDG, differences are identified in the carriers with very mild cognitive changes (CDR 0.5, M+, middle). Changes in cortical thickness are only identified in the cohort with mild dementia (CDR> 1⁄4 1, M+).