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P3‐092: Subjective cognitive complaint and cognitive performance among older adults
Author(s) -
Gifford Katherine,
Der Aaron,
Romano Raymond,
Martin Brett,
Cantwell Nicole,
Kowall Neil,
Jefferson Angela
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1311
Subject(s) - complaint , psychology , cognition , conversation , neuropsychology , episodic memory , everyday life , association (psychology) , clinical psychology , developmental psychology , audiology , medicine , psychiatry , communication , political science , law , psychotherapist
(ETCO 2) was recorded simultaneously. Stepwise multiple linear regression analysis was used to examine the effects of MAP, ET CO 2, group (0 for control, 1 for MCI), age and gender (0 for female, 1 for male) on VMCA, F ICA, and F VA (, percentage changes to baseline).Results: The range of variations inMAP induced by drug infusionwas 65w143mmHg associatedwith a concomitant change in ETCO2 (range: 22w48 mm Hg). The regression equations derived were: VMCA 1⁄4 0.170*MAP + 0.530* ETCO2 + 0.189*Group + 0.252*Age, R 1⁄4 0.719, P < 0.001; FICA 1⁄4 0.212* ETCO2, R 1⁄4 0.237, P < 0.01; FVA 1⁄4 0.221*MAP + 0.262* ETCO2 + 0.256*Group, R 1⁄4 0.475, P < 0.001. Significantly different CBF responses to MAP and ETCO2 between the MCI and control groups were observed in the MCA and VA, but not in the ICA. No gender differences were observed.Conclusions: Cerebral autoregulatory dysfunction was detected in patients with MCI, most prominently in the MCA and posterior cerebral territory (supplied mainly by the VA). These findings suggest that cerebrovascular dysfunction is detectable at the early stage of AD. A cause-effect relationship has yet to be established.