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P3‐075: Simultaneous inhibition of COX‐2 and activation of PPAR‐γ resulted in the same level and pattern of neuroprotection as they were targeted separately
Author(s) -
Abraki Shahnaz Babaei,
Khalaj Leila,
Khodagholi Fariba
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1294
Subject(s) - neuroprotection , peroxisome proliferator activated receptor , apoptosis , viability assay , cyclooxygenase , chemistry , western blot , neuroinflammation , pharmacology , mtt assay , oxidative stress , receptor , arachidonic acid , cell culture , biology , microbiology and biotechnology , biochemistry , inflammation , enzyme , immunology , genetics , gene
model has 13 compartments, 442 species, 260 reactions and 326 parameters derived from expression levels for 380 genes. Time-series simulations were run using ordinary differential equations to generate level values for reactants and flux values for reactions. Conclusions: These results on the glutathione pathway are discrepant with enzyme activities reported for the frontal cortex in AD, and can be explained as regional differences and that ex vivo studies use identical substrate concentrations, whereas, biosimulated substrate levels arise from network behavior. The apoptosis-marker results are consistent with the abortosis hypothesis for AD.