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P3‐042: Pathogenesis of brain degeneration and cognitive impairment in diabetes: Implications for Alzheimer's disease
Author(s) -
Ishii Douglas,
Serbedzija Predrag
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1260
Subject(s) - endocrinology , medicine , atrophy , glial fibrillary acidic protein , immunostaining , diabetes mellitus , hippocampus , neurofilament , astrogliosis , brain damage , cerebrospinal fluid , pathology , immunohistochemistry , central nervous system
the AD group compard with controls. After stratified age adjustment, copper (1146.26 6 188.68 mg/dl, p 1⁄4 0.049) alone was significantly higher in AD group. Serum copper levels correlated with good results on the Boston naming test (r 1⁄4 -0.151, p 1⁄4 0.037). Conclusions: High copper level may play a role in the neurodegenerative processes of AD.We need furthur studies to show the impact of high serum copper on the onset or progessin of ADmore directly.