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P3‐035: Transcriptome‐to‐reactome biosimulation: Basal forebrain cholinergic neuron neurotrophin signaling
Author(s) -
Phelix Clyde,
Rahimi Omid,
Colom Luis,
Perry George,
Ginsberg Stephen
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1253
Subject(s) - tropomyosin receptor kinase a , basal forebrain , tropomyosin receptor kinase b , neurotrophin , low affinity nerve growth factor receptor , cholinergic , nerve growth factor , cholinergic neuron , biology , brain derived neurotrophic factor , neuroscience , neurotrophic factors , medicine , endocrinology , receptor , microbiology and biotechnology
PKA. Conclusions: Because tau phosphorylation at Ser214 may prime tau for further phosphorylation by other kinases, our findings provide a novel possible mechanism by which rapamycin reduces or prevents tau hyperphosphorylation. P3-035 TRANSCRIPTOME-TO-REACTOME BIOSIMULATION: BASAL FOREBRAIN CHOLINERGIC NEURON NEUROTROPHIN SIGNALING Clyde Phelix, Omid Rahimi, Luis Colom, George Perry, Stephen Ginsberg, University of Texas at San Antonio, San Antonio, Texas, United States; University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States; University of Texas at Brownsville, Brownsville, Texas, United States; 4 New York University Langone Medical Center, Orangeburg, New York, United States.