Premium
P3‐035: Transcriptome‐to‐reactome biosimulation: Basal forebrain cholinergic neuron neurotrophin signaling
Author(s) -
Phelix Clyde,
Rahimi Omid,
Colom Luis,
Perry George,
Ginsberg Stephen
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1253
Subject(s) - tropomyosin receptor kinase a , basal forebrain , tropomyosin receptor kinase b , neurotrophin , low affinity nerve growth factor receptor , cholinergic , nerve growth factor , cholinergic neuron , biology , brain derived neurotrophic factor , neuroscience , neurotrophic factors , medicine , endocrinology , receptor , microbiology and biotechnology
PKA. Conclusions: Because tau phosphorylation at Ser214 may prime tau for further phosphorylation by other kinases, our findings provide a novel possible mechanism by which rapamycin reduces or prevents tau hyperphosphorylation. P3-035 TRANSCRIPTOME-TO-REACTOME BIOSIMULATION: BASAL FOREBRAIN CHOLINERGIC NEURON NEUROTROPHIN SIGNALING Clyde Phelix, Omid Rahimi, Luis Colom, George Perry, Stephen Ginsberg, University of Texas at San Antonio, San Antonio, Texas, United States; University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States; University of Texas at Brownsville, Brownsville, Texas, United States; 4 New York University Langone Medical Center, Orangeburg, New York, United States.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom