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IC‐P‐089: White matter damage in posterior cortical atrophy assessed in vivo using diffusion tensor magnetic resonance imaging
Author(s) -
Keihaninejad Shiva,
Zhang Hui,
Shakespeare Tim,
Ryan Natalie,
Malone Ian,
Frost Chris,
Cardoso Manuel,
Modat Marc,
Lehmann Manja,
Thornton John,
Warren Jason,
Cash David,
Crutch Sebastian,
Ourselin Sebastien,
Fox Nick
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.122
Subject(s) - fractional anisotropy , white matter , diffusion mri , spatial normalization , magnetic resonance imaging , nuclear medicine , medicine , atrophy , region of interest , nuclear magnetic resonance , psychology , pathology , radiology , physics
4.2, duration 1.5 6 0.8) and 16 healthy control (HC: age 63.3 6 11.0, MMSE 28.3 6 1.1) (mean 6 SD). Forty minutes dynamic scan with arterial blood sampling was conducted after intravenous injection of N -[11 C]methyl-4-piperidyl acetate ([11 C]MP4A). Realignment, spatial normalization and smoothing were performed by SPM2 and 2 tissue 3 parameter model non-linear least square estimation was used to calculate voxel-wise brain AChE activity. Brain mask excluding cerebellum and striatum was applied. Voxel-based group comparison and correlation analysis were performed followed by VOI analysis. Clusters were accepted as significant if Family-Wise Error corrected P values<0.05 in cluser-level with extent threshold above 30 voxels. Results: Parametric group comparison showed that AChE activity was widely attenuated in neocortex of EOAD group while the AChE reduction was relatively restricted to temporo-parietal area in LOAD group. Significant differences between EOAD and LOAD groups were found in bilateral superior temporal and inferior parietal region. Regional AChE activity of left Wernicke’s area was positively correlated with age in AD. VOI analysis showed, when compared with HC, mean cortical AChE activity was reduced by 19.0% in EOAD (P<0.001) and 11.5% in LOAD (P<0.001), different between EOAD and LOAD (P 1⁄4 0.005). Conclusions: Younger age is associated with lower cortical AChE activity in AD patients. Age should be considered as an important factor for AD patients when treating with AChE modulating agents.