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O3‐12‐06: Comparison of visual and quantitative florbetapir‐PET reads in subjects with early Alzheimer's disease for assessing amyloid burden
Author(s) -
Peng Yahong,
Wyman Bradley,
Lobello Kasia,
Zubal George,
Ryan Michael,
Marek Kenneth,
Seibyl John,
Slomkowski Mary
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1211
Subject(s) - posterior cingulate , medicine , visual cortex , cingulum (brain) , psychology , pathology , neuroscience , cortex (anatomy) , magnetic resonance imaging , radiology , white matter , fractional anisotropy
(60%) controls, 21/26 (81%) MCI and 42/45 (93%) AD subjects who were early-PiB(+) remained AD-like-PiB(+). Conclusions: Cutoffs designed to detect the very first signs of amyloid deposition in cognitively normal controls may be too liberal to accurately ascribe the underlying pathophysiology of a clinical dementia syndrome to AD. A more conservative cutoff may be necessary to increase the specificity of amyloid imaging for the identification of clinical dementia (or even MCI) syndromes caused by AD.