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O3‐10‐05: Prevalence of mild cognitive impairment and its etiological subtypes in rural and urban populations in China
Author(s) -
Jia Jianping,
Wu Xuan
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1199
Subject(s) - etiology , medicine , epidemiology , dementia , neuropsychology , population , cognitive impairment , disease , pediatrics , gerontology , demography , cognition , psychiatry , environmental health , sociology
(NPI-Q) total score. We modeled medication use and then used the resulting propensity scores to match individuals with PI>1⁄4.3 to those never exposed (PI1⁄40) on a 1:1 basis. Associations between medication use and outcomes were estimated with random-effects models controlling for baseline age, sex, education, and use of anti-dementia medications. Results: 4457 participants with AD had at least one follow up visit. Mean (SD) age at baseline was 75.9(9.4), 14.3(3.8) years education, and 2081(57.1%) were male. Mean (SD) MMSE was 21.1(6.4), CDR-Sum 5.8(4.2), and NPI-Q Total 4.2(4.4). The mean (median) duration of follow up was 2.2 (2.08) years. Use of all psychotropic medication classes was associated with more rapid rate of increase in CDR-Sum and with more rapid rate of decrease in MMSE. High PI for SSRIs antipsychotics, and atypical antipsychotics was associated with more rapid rate of increase in NPI-Q Total. Conclusions: The use of PS matching allowed us to control for clinical variables and confounding by indication thus providing a stronger level of inference than prior studies. Thus, psychotropic medication use may be associated with poorer AD outcomes and merit further study, ideally in randomized controlled trials.