Premium
O3‐09‐03: Longitudinal reduction in blood pressure in hypertensive individuals is associated with increased levels of biomarkers for Alzheimer's disease
Author(s) -
Glodzik Lidia,
Rusinek Henry,
McHugh Pauline,
Pirraglia Elizabeth,
Williams Schantel,
Cummings Megan,
Rich Kenneth,
Randall Catherine,
Mosconi Lisa,
Osorio Ricardo,
Zetterberg Henrik,
Blennow Kaj,
De Leon Mony
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1191
Subject(s) - blood pressure , medicine , cerebral blood flow , cerebral perfusion pressure , cardiology , hemodynamics , longitudinal study , perfusion , cerebrospinal fluid , disease , cognitive decline , pathology , dementia
this process is established, neuritic plaques are more deleterious to cognition in Africans than in Caucasians. Considering that the studied population share similar demographics and dwells in an acculturated city, we hypothesize that these differences are product of genetics. Several gene variations related to the amyloid cascade have been identified in GWAS. To determine if these variations impact varies according to ethnicity may lead to a better understanding about protective and risk factors to AD and suggest the need of ethnic-based therapeutic schemes.