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O3‐06‐04: Effects of omega‐3 supplementation on brain structure and function in healthy elderly subjects
Author(s) -
Witte Veronica,
Kerti Lucia,
Flöel Agnes
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1174
Subject(s) - fractional anisotropy , white matter , diffusion mri , neuropsychology , medicine , brain structure and function , psychology , magnetic resonance imaging , nuclear medicine , neuroimaging , cognition , psychiatry , radiology
were referenced to total intracranial volume and WMH volume was referenced to total WM volume. We used Cox proportional hazards estimates to assess the effect of MRI and MRS markers on the hazard of progression from cognitively normal to MCI. Results: After a median follow-up of 2.8 years, 205 participants were diagnosed as MCI (estimated incidence rate1⁄4 6.2%per year). In univariablemodeling, hippocampal volume,WMHvolume and MRS metabolite ratios: NAA/creatine (Cr), mI/Cr, NAA/mI (p<0.001) and choline (Cho)/Cr (p<0.05) were significant predictors of MCI in cognitively normal older adults with or with-out age adjustment. There was equivocal evidence that cortical infarctions 1 cm were associated with MCI risk (p1⁄40.05) but this association was not significant after adjusting for age. In multivariable modeling accounting for age, only hippocampal volume and NAA/mI were independent predictors of MCI. Conclusions: MRI and MRS markers of AD-related neurodegeneration and WMH are significant predictors of MCI in cognitively normal adults. Hippocampal atrophy and NAA/mI reduction independently increase the risk ofMCI in cognitively normal older adults therefore MRS may potentially contribute to the assessment of preclinical dementia pathologies in capturing neurodegenerative changes not reflected by hippocampal atrophy.