Premium
O3‐05‐05: Effect of Aβ burden and apolipoprotein E‐ε4 on cognitive decline at 18 months in healthy older adults
Author(s) -
Lim Yen Ying,
Ellis Kathryn,
Ames David,
Harrington Karra,
Martins Ralph,
Masters Colin,
Rowe Christopher,
Savage Greg,
Szoeke Cassandra,
Villemagne Victor,
Pietrzak Robert,
Maruff Paul
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1168
Subject(s) - apolipoprotein e , neuropsychology , cognition , effects of sleep deprivation on cognitive performance , cognitive decline , medicine , episodic memory , gerontology , psychology , audiology , dementia , psychiatry , disease
ory test (RMT) scores at baseline (age adjusted means: 43.1 vs 46.2, P1⁄40.004). Over the presymptomatic period, there was a relative reduction in verbal RMT scores in converters compared with controls (median change: -2 vs. +1; p1⁄40.04). By the time symptoms occurred, performance in several other domains including verbal IQ, visual recognition memory and executive function also showed relative deterioration from baseline in the converters compared with controls. Conclusions: These results suggest subtle deficits in verbal recognition memory are present as early as five years before onset of symptoms in FAD;memory scores decline during the presymptomatic period and by symptom onset multiple cognitive domains have shown relative deterioration. As symptom onset precedes the diagnosis of Alzheimer’s disease by many years, these results have implications for trials aiming to institute treatments before significant cognitive deficits have occurred in at-risk FAD individuals.