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O3‐05‐04: Longitudinal presymptomatic cognitive changes in individuals at risk of familial Alzheimer's disease
Author(s) -
Liang Yuying,
Crutch Sebastian,
Nicholas Jennifer,
Ryan Natalie,
Warrington Elizabeth,
Shakespeare Tim,
Yeatman Tom,
Rossor Martin,
Fox Nick
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1167
Subject(s) - neuropsychology , medicine , asymptomatic , cohort , disease , cognitive decline , dementia , cognition , psychology , audiology , psychiatry
Background: Few studies have systematically analyzed the earliest neuropsychological deficits in familial Alzheimer’s disease (FAD). As individuals at risk of FAD are potential candidates for disease-modifying treatment trials, it is important to characterize the changes in the presymptomatic stage. Here we present the results from a local FAD cohort followed for up to two decades. Methods: Fifty-four asymptomatic at risk individuals from families with presenilin 1 and amyloid precursor protein mutations were recruited into the study. Each had two to 16 neuropsychology assessments approximately annually and was followed for up to 20 years. Eighteen subjects subsequently became affected (converters); 36 remained well (controls). Symptom onset was defined by the appearance of the first progressive decline in cognition or behavior on prospectively collected clinical information. We compared neuropsychology scores between the two groups at baseline and the changes in scores over the presymptomatic period (between the baseline and the last assessment prior to symptom onset). Statistical significancewas assessed using theMann-WhitneyU test or t-test for variables with normal distribution. Age adjusted differences at baseline were estimated using linear regression with bootstrap standard errors. Results:Amongst the converters mean (SD) time from baseline to symptom Carrier v Noncarrier e4 Homozygote v Noncarrier e4 Heterozygote v Noncarrier