Premium
IC‐P‐083: Association between brain amyloidosis, synaptic dysfunction and cognitive performance measured with ADAS‐cog and MMSE scores in early MCI, late MCI and Alzheimer's disease
Author(s) -
Dauar Marina,
Rowley Jared,
Wu Liyong,
Shin Monica,
Mohades Sara,
Fonov Vladimir,
Leuzy Antoine,
Gauthier Serge,
RosaNeto Pedro
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.116
Subject(s) - dementia , clinical dementia rating , neuropsychology , medicine , temporal lobe , voxel , cognition , audiology , psychology , alzheimer's disease , nuclear medicine , neuroscience , disease , radiology , epilepsy
dorsal anterior cingulate, posterior cingulate and the insula were associated with the main effects of depression, increased GM atrophy in the thalamus, and default mode, executive control and medial temporal lobe (MTL) regions were related to the main effects of aMCI. Depression-aMCI interactive effects were associated with global GM volume loss involving cortical and MTL structures (P<0.05 FDR corrected; Figure 1). Depressive symptoms were negatively correlated and episodic memory performances were positively associated with GMV in similar brain regions as observed with LLD and aMCI respectively. Depressive symptom-memory deficit interactive effects were also seen globally, especially in the DMN and MTL regions. Conclusions: The interactive effects of LLD and aMCI are associated with GMV loss in crucial cognition and mood regulation structures. The co-existence of these clinical phenotypes may be a marker of AD. IC-P-083 ASSOCIATION BETWEEN BRAIN AMYLOIDOSIS, SYNAPTIC DYSFUNCTION AND COGNITIVE PERFORMANCE MEASUREDWITH ADAS-COG AND MMSE SCORES IN EARLY MCI, LATE MCI AND ALZHEIMER’S DISEASE Marina Dauar, Jared Rowley, Liyong Wu, Monica Shin, Sara Mohades, Vladimir Fonov, Antoine Leuzy, Serge Gauthier, Pedro Rosa-Neto, McGill Center for Studies in Aging, Montreal, Quebec, Canada; 2 McGill University, Verdun, Quebec, Canada; 3 McGill Center for Studies in Aging, Verdun, Quebec, Canada; 4 McGill University, Verdun, Quebec, Canada; Montreal Neurological Institute, Montreal, Quebec, Canada; McGill Centre for Studies in Aging, Montreal, Quebec, Canada; 7 Alzheimer Disease Research Unit, McGill Center for Studies in Aging, Montreal, Quebec, Canada; 8 McGill University, Montreal, Quebec, Canada.