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P2‐395: Allopregnanolone analogues promote proliferation of neural progenitor cells
Author(s) -
Chen Shuhua,
Tusty Mahbuba,
Johnstone Timothy,
Hogenkamp Derk,
Gee Kelvin,
Brinton Roberta
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1105
Subject(s) - neurosphere , neural stem cell , neurogenesis , progenitor cell , biology , stem cell , cell sorting , microbiology and biotechnology , cell growth , bromodeoxyuridine , allopregnanolone , genetically modified mouse , in vivo , transgene , adult stem cell , in vitro , flow cytometry , endothelial stem cell , biochemistry , neuroactive steroid , receptor , gene , gabaa receptor
strategy is a novel approach in designing multifunctional compounds that target multiple risk factors involved in AD development. CM/LR anchorage can efficiently increase the accessbility and efficacy of the multifunctional warhead in the bivalent compounds. These bivalent compounds can serve as both potential lead compounds for effective AD-modifying agents and pharmacological tools to help unravel the cooperative roles of the multiple risk factors in the pathogenesis of AD.