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IC‐P‐075: Evidence for dissociable patterns of PiB retention during early stages of amyloid accumulation
Author(s) -
Mormino Elizabeth,
Schultz Aaron,
Becker John,
Gidicsin Christopher,
Pepin Lesley,
Rentz Dorene,
Maye Jacqueline,
Amariglio Rebecca,
Marshall Gad,
Sperling Reisa,
Johnson Keith
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.108
Subject(s) - pittsburgh compound b , precuneus , psychology , analysis of variance , dementia , amyloid (mycology) , medicine , cardiology , cognitive impairment , cognition , pathology , neuroscience , disease
ing-in phenomenon with voxel-based morphometry (VBM) method. Methods: Thirty-eight patients diagnosed as probable Alzheimer’s disease (AD) and twenty-one normal controls were included for this study. All subjects underwent neuropsychological test to diagnose dementia and MPRAGE brain MRI for voxel based statistical analysis. They were asked to copy the modified Luria‘s alternating square & triangle to quantification of closing-in phenomenon. We used SPM8 for the VBM analysis to find gray matter loss associated with closing-in score. Results: AD patients showed a higher closing-in phenomenon score than the normal controls. (P<0.0001) OnVBM analysis, the AD patients havemore parietal and temporal atrophy than normal controls in group comparison, and the atrophy of bilateral orbito-frontal area was associated with the closing-in phenomenon score. Conclusions: Bilateral orbito-frontal areas are anatomical correlates of closing-in phenomenon. This may reveal that closing-in phenomenon is one of the imitation behaviors commonly observed in patients with frontal lobe damage.