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P2‐324: The effects of fermented Crassostrea gigas extraction on TMT‐induced amnesic rats
Author(s) -
Shim Hyun Soo,
Park Hyun Jung,
Ahn Yong Ho,
Hahm DaeHyun,
Lee Hyejung,
Shim Insop
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1033
Subject(s) - morris water navigation task , choline acetyltransferase , saline , cholinergic , intraperitoneal injection , water maze , endocrinology , medicine , psychology , chemistry , anesthesia , hippocampus
professionals through crisis review. The Neuropsychiatric Inventory Questionnaire (NPI-Q) and Geriatric Depression Scale (GDS) were used to measure the impact of neuropsychiatric symptoms and Bridge interventions on both patient with AD and caregivers. Results: The Bridge project led to significantly reduced patient anxiety, depression, resistance to care, impulsive behavior, verbal outbursts, hallucinations, wandering, and paranoia. Patient NPI-Q responses demonstrated significantly reduced total neuropsychiatric symptoms following intervention. Caregivers demonstrated significantly reduced anxiety, apathy, resistance to care, and reported significantly less distress over patient neuropsychiatric symptoms. Caregivers reported increased confidence in their ability to manage difficult behaviors and reported that the Bridge project was effective in reducing or resolving neuropsychiatric crisis. The Bridge project delayed nursing home placement for community dwelling patients at risk of placement.Conclusions: Crisis support models like the Kansas Dementia Crisis Bridge Project reduce strain on the too few available systems by incorporating non-pharmacological interventions when possible, assisting families with communicating with geriatric psychiatric physicians/hospitals when needed, and supporting through the most distressing aspects of the disease. While much of Alzheimer’s disease research focuses on disease modifying medical interventions, state aging and care systems must simultaneously move towards dependency on modifying care interventions.