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P2‐315: Cognitive function and mobility disability in older adults with amnestic mild cognitive impairment
Author(s) -
McGough Ellen,
McCurry Susan,
Logsdon Rebecca,
Pike Kenneth,
Teri Linda
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1024
Subject(s) - dementia , geriatric depression scale , cognition , gerontology , logical address , cognitive decline , psychology , medicine , physical medicine and rehabilitation , physical therapy , disease , psychiatry , depressive symptoms , physical address , computer science , programming language , overlay
2011. While scores steadily increased, the first significant difference in mean scores from 1991 was in 2003 (p <0.05). Significant differences were also observed in mean ADAS-cog scores [(F(20,1341) 1⁄4 6.16, p<0.0001], with an average decrease of 4 points over the 20-year period. Mean ADAS-cog scores initially increased (worsened) until 1995 and steadily decreased (improved) thereafter. Daily functioning, as measured by the ADL, improved 7 percent from 1991 to 2011 [F(19,1143) 1⁄4 3.32, p<.0001]. Mean reported impairment increased slightly from 1991 to 1995 and subsequently decreased. Conclusions: The results suggest that people are being diagnosed earlier in the disease process. Previous studies indicate that in patients with AD, MMSE scores decline an average of 3 points per year and ADAS-cog scores are increased by 7 points per year. Our results suggest that on average, at initial evaluation, patients’ MMSE scores have increased by 6 points and ADAS-cog scores decreased by 4 points over the past 20 years. Impairment in daily functioning has significantly decreased over time as well. Taken together, the findings suggest patients are diagnosed 6 months to 2 years earlier in the disease process, which may lead to improvement in treatment outcomes.