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IC‐P‐048: Visualizing stages of cortical atrophy in progressive MCI from the ADNI cohort
Author(s) -
Eskildsen Simon,
Fonov Vladimir,
Coupe Pierrick,
Collins Louis
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.080
Subject(s) - atrophy , parahippocampal gyrus , temporal lobe , neuroimaging , alzheimer's disease neuroimaging initiative , gyrus , cardiology , medicine , cohort , alzheimer's disease , psychology , neuroscience , disease , radiology , epilepsy
Amnestic mild cognitive impairment (MCI) is considered a condition where patients are at risk of developing clinically definite Alzheimer's disease (AD) with an annual conversion rate of approximately 15%. AD is characterized by progressive brain atrophy with major impact on the cerebral cortex and medial temporal lobe structures such as hippocampus. Understanding the structural pattern of cortical atrophy at different stages of MCI, before AD can be diagnosed, may help in patient monitoring and prognosis. In this study, we used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to calculate and visualize the cortical atrophy at different stages in patients who eventually converted to clinically definite AD.