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National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
Author(s) -
Hyman Bradley T.,
Phelps Creighton H.,
Beach Thomas G.,
Bigio Eileen H.,
Cairns Nigel J.,
Carrillo Maria C.,
Dickson Dennis W.,
Duyckaerts Charles,
Frosch Matthew P.,
Masliah Eliezer,
Mirra Suzanne S.,
Nelson Peter T.,
Schneider Julie A.,
Thal Dietmar Rudolf,
Thies Bill,
Trojanowski John Q.,
Vinters Harry V.,
Montine Thomas J.
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.10.007
Subject(s) - senile plaques , hippocampal sclerosis , neuropathology , alzheimer's disease , disease , lewy body disease , medicine , pathology , neuroscience , psychology , dementia , dementia with lewy bodies , temporal lobe , epilepsy
A consensus panel from the United States and Europe was convened recently to update and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's disease (AD) and other diseases of brain that are common in the elderly. The new guidelines recognize the pre‐clinical stage of AD, enhance the assessment of AD to include amyloid accumulation as well as neurofibrillary change and neuritic plaques, establish protocols for the neuropathologic assessment of Lewy body disease, vascular brain injury, hippocampal sclerosis, and TDP‐43 inclusions, and recommend standard approaches for the workup of cases and their clinico‐pathologic correlation.