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P4‐366: Frontotemporal lobal involvement in advanced amyotrophic lateral sclerosis‐CT imaging study
Author(s) -
Watanabe Chigusa,
Katayama Sadao,
Makino Takako,
Higaki Masahiro,
Horie Nobuko
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.09.180
Subject(s) - frontotemporal dementia , amyotrophic lateral sclerosis , frontotemporal lobar degeneration , atrophy , medicine , dementia , progressive muscular atrophy , executive dysfunction , disease , pathology , neuroscience , physical medicine and rehabilitation , cognition , psychology , psychiatry , neuropsychology
Background:Amyotrophic lateral sclerosis (ALS) is recently recognized to be a multisystem disorder which includes both clinical and neuropathological features of a frontotemporal lobar degeneration (FTLD). Frontotemporal dementia, or disorders of frontotemporal function, such as behavioural, cognitive and executive dysfunction, may occur in precede the development of motor deficits or insidiously following the motor dysfunction.Methods: In order to clarify the characteristics of the brain imaging of CT in advanced ALS patients. We performed CT examination in 27 cases of clinically definite ALS patients(M:F 13:14, age 63.86 9.4 years, disease duration 8.16 2.9 years)according to the El Escorial criteria. Three patients had showed clinically dementia. We evaluated the levels of lobar atrophy semi-quantitatively. Results: In all patients, 22 patients (81.4%) showed moderate to severe frontotemporal lobar atrophy. It is likely that the levels of atrophy reflect the communication ability. Conclusions:We suggest that frontotemporal lobal involvement may occur commonly in the ALS patients and influence the communication ability and QOL.