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P4‐358: Different hierarchical cytoarchitectonic sub‐type vulnerability to Aβ‐deposits and gray matter loss in AD and MCI patients: A comparison between a young and old cohort
Author(s) -
Ng YenBee,
Nordberg Agneta,
Carter Stephen,
Schöll Michael,
Kadir Ahmadul
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.09.173
Subject(s) - cohort , atrophy , pathology , neocortex , psychology , neuroscience , medicine
Background:Amyloid beta (Aß) deposits demonstrate specific regional and laminar distributions with selective preponderance in the superficial cortical layers in post-mortem AD brains. Considering that Aß initiates significant synaptic and neuronal degeneration it poses the intriguing question as to which subtypes of cytoarchitectonic properties of the brain are more vulnerable to Aß and gray matter loss between different age cohorts.Methods:We addressed this issue by investigating Aß-deposits measured with 11C-PIBPETand gray matter (GM) volume, using structural T1MRI, in healthy controls, MCI PIB+, MCI PIBand AD patients. MCI PIB+ was defined by a cut-off value of global cortical 11C-PIB retention > 1.41. A comparison between a young (Karolinksa Institutet KI, mean age < 65) and old (ADNI mean age > 75) cohort was performed. A cytoarchitectonic probabilistic atlas with six cytoarchitectonic sub-types (granular, dysgranular, agranular, allocortex, periallocortex, corticoid) was adopted to investigate brain images. Results: There was no difference in MMSE score between young and old cohorts within each clinical group. Comparing AD and MCI PIB+ to MCI PIBand healthy control subjects within KI cohort demonstrated neocortex, inclusive of granular, dysgranular, and agranular, had abundant Aß-deposits but without significant brain atrophy, while limbic areas composed of allocortex and periallocortex appeared less vulnerable by Aß-deposits but had severe GM loss. These distinct cytoarchitectonic vulnerabilities were less robust in the older ADNI cohort. MCI PIB+ subjects of the KI cohort had significant agranular and corticoid Aß-deposits,