Premium
P4‐469: Chronic treatment with rivastigmine does not modify primary motor cortex synaptic plasticity in patients with Alzheimer's disease (AD): a repetitive transcranial magnetic stimulation (rTMS) study
Author(s) -
Trebbastoni Alessandro,
D'Antonio Fabrizia,
Campanelli Alessandra,
Gabriele Maria,
Prencipe Massimiliano,
Inghilleri Maurizio,
De Lena Carlo
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.09.162
Subject(s) - transcranial magnetic stimulation , rivastigmine , psychology , neuroscience , medicine , synaptic plasticity , silent period , neuroplasticity , stimulation , dementia , disease , donepezil , receptor
cognitive complaint. The current study examined baseline subjective complaints as a predictor of diagnostic outcome in MCI over a 3-year follow-up period. Methods: Participants were drawn from National Alzheimer’s Coordinating Center (NACC) extant data, and included 1828 individuals with a baseline diagnosis of MCI (746 11 years old; 57% female). Baseline subjective memory complaint status was categorized as 1) no complaint, 2) self-complaint only, 3) informant-complaint only, and 4) selfand informant-complaint to predict diagnostic outcome over the follow-up period. Results: At follow-up, 581 individuals (32%) had converted to dementia whereas 1247 individuals (68%) had remained stable or reverted to normal. Logistic regression compared conversion status in subjects with no complaint in relation to each of the three groups with some type of complaint (self-complaint, informant-complaint, selfand informant-complaint). As compared to non-complainers, significant differences in odds ratios were detected for informant complaint only (OR 1⁄4 2.8; 95% CI 4.0-2.4; p 1⁄4 0.002) and selfand informant-complaint (OR 1⁄4 3.21; 95% CI 5.2-2.4, p <0.001). Conclusions: The current findings highlight the diagnostic importance of a subjective cognitive complaint in the accurate classification of individuals with MCI who are at greatest risk for conversion to dementia. Informant-complaint as compared to self-complaint may be more sensitive in identifying individuals at risk for conversion.