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P4‐437: Repeated baseline cognitive measurements in mild to moderate AD patients reveal significant day‐to‐day variation
Author(s) -
Zettergren Annica,
Jaeger Judith,
Hardemark HansGoran,
Hannesdottir Kristin,
Sjögren Niclas
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.09.133
Subject(s) - medicine , analysis of variance , repeated measures design , cognition , randomization , day to day , psychology , audiology , randomized controlled trial , statistics , psychiatry , mathematics , operations management , economics
immunogens in the culture media, DCs from As immunogens-immunized APP/PS1 transgenic mice showed stronger migration, endocytosis and higherMHC II expression than DCs from unimmunizedmice. Further, short As immunogens decreased the secretion of IL-12/IL-10, IL-6/IL-1s and increased the production of TGF-s by DCs from immunized APP/PS1 transgenic mice, but not those from unimmunized mice. Our data indicated that DCs from APP/PS1 transgenic mice were in low-response state to short As immunogens in vitro. Furthermore, immunization with short As immunogens in vivowaked up this abnormal state.Conclusions:Therefore, it is necessary to take abnormal DCs role into consideration in As immunotherapy.