P4‐437: Repeated baseline cognitive measurements in mild to moderate AD patients reveal significant day‐to‐day variation | Zendy

Zettergren Annica | Zendy; Jaeger Judith | Zendy; Hardemark HansGoran | Zendy; Hannesdottir Kristin | Zendy; Sjögren Niclas | Zendy

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P4‐437: Repeated baseline cognitive measurements in mild to moderate AD patients reveal significant day‐to‐day variation

Author(s) -

Zettergren Annica,

Jaeger Judith,

Hardemark HansGoran,

Hannesdottir Kristin,

Sjögren Niclas

Publication year - 2011

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2011.09.133

Subject(s) - baseline (sea) , variation (astronomy) , day to day , repeated measures design , cognition , time of day , medicine , psychology , statistics , mathematics , zoology , biology , psychiatry , physics , engineering , operations management , fishery , astrophysics

immunogens in the culture media, DCs from As immunogens-immunized APP/PS1 transgenic mice showed stronger migration, endocytosis and higherMHC II expression than DCs from unimmunizedmice. Further, short As immunogens decreased the secretion of IL-12/IL-10, IL-6/IL-1s and increased the production of TGF-s by DCs from immunized APP/PS1 transgenic mice, but not those from unimmunized mice. Our data indicated that DCs from APP/PS1 transgenic mice were in low-response state to short As immunogens in vitro. Furthermore, immunization with short As immunogens in vivowaked up this abnormal state.Conclusions:Therefore, it is necessary to take abnormal DCs role into consideration in As immunotherapy.

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