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P4‐356: MRI‐derived cortical thickness measurements from APP transgenic mice
Author(s) -
Hebert Francois,
Ho MingKai,
Lerch Jason,
Hamel Edith,
Bedell Barry
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.09.101
Subject(s) - magnetic resonance imaging , genetically modified mouse , cerebral cortex , cortex (anatomy) , pathology , biology , anatomy , medicine , biomedical engineering , neuroscience , transgene , radiology , gene , biochemistry
phyof theMTLwas 26.7%-35.6%.TheVBMOF24 pureADpatients showed that parietal lobe atrophy was the most severe part of the cortical atrophy. The FDG-PET follow up of a few cases showed us that the hypometabolism in the parietal lobe occurred earlier than in the post cingulate. The hypometabolism of theMTLwas extendedmore later.Conclusions: The hypometabolism and cortex atrophy of the parietal lobe could be valuable for AD diagnosis.