Premium
P4‐331: The effects of head circumference and lifetime alcohol consumption on cognitive function in the elderly
Author(s) -
Lee Kang Soo
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.09.076
Subject(s) - cognition , alcohol consumption , anthropometry , circumference , gerontology , medicine , head circumference , cognitive decline , psychology , alcohol , demography , dementia , psychiatry , mathematics , pregnancy , biochemistry , chemistry , geometry , sociology , biology , genetics , gestational age , disease
domains were effective in imaging kinase activities, kinase inhibitors, and phosphatase inhibitors in solution, in cell extracts, in fixed cells, and in living cells. The fluorescence sensors exhibited rapid response and large dynamic range. The sensors functioned to detect dynamic kinase and phosphatase activities in cells. The strategy is broadly applicable to the detection of the activities of protein kinases and protein phosphatases.Conclusions:A series of small, genetically encodable protein tags were developed that can act as highly sensitive fluorescent sensors of cdk5, GSK-3, MARK, Fyn, or other kinase activities. It is applicable for the analysis of kinase activity in cell extracts, in fixed cells, and in living cells. This tag is available as a general tool for studies of kinase activity and phosphatase activity in Alzheimer’s disease.