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P4‐313: Age of dementia onset delayed by bilingualism, but advanced by stroke
Author(s) -
Alladi Suvarna,
Shailaja Mekala,
Santhoshi Chadalawada,
Nigam Richa,
Kaul Subhash
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.09.058
Subject(s) - dementia , vascular dementia , stroke (engine) , medicine , disease , risk factor , diabetes mellitus , gerontology , psychology , endocrinology , mechanical engineering , engineering
dementia. The risk for dementia according to the NIA-AA criteria was 57% (high likelihood), 47% (intermediate likelihood), and 11% (low likelihood). Subjects with a NIA-AA uninformative score had a 31% risk for dementia. The sensitivity to detect dementia was highest for the IWG criteria and NIAAA intermediate likelihood criteria based on CSF abeta42 (78%) and lowest for the NIA-AA high likelihood criteria (53%, see table). Conclusions: IWG and NIA-AA criteria differ in progression rate and sensitivity. The likelihood levels in the NIA-AA criteria correlate with 2-year dementia risk. Subjects with a NIA-AA ‘uninformative’ score due to conflicting biomarker results have an increased risk for AD-type dementia compared to subjects with normal scores for both biomarkers. This suggests that conflicting biomarker scores may be informative.