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O4‐08‐03: Loss of tau induces age‐dependent neurodegeneration
Author(s) -
Lei Peng,
Ayton Scott,
Wright David,
Ciccotosto Giuseppe,
Cappai Roberto,
Duce James,
Finkelstein David,
Bush Ashley
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.09.016
Subject(s) - corpus callosum , neurodegeneration , morris water navigation task , striatum , neuroscience , atrophy , medicine , rotarod performance test , dopaminergic , dopamine , psychology , endocrinology , pathology , disease , hippocampus , motor activity
fied. Results: In asymptomatic individuals, the levels of Aß56 showed an age-related increase and strongly correlated with CSF tau/Aß42, one of the best-performing biomarkers of AD. Aß56 levels also distinguished AD subjects from those with subcortical vascular dementia (SVD), supporting a specific involvement in AD. While LMW oligomers strongly correlated with CSF tau/Aß42 and trended towards an age related-increase in asymptomatic subjects, they failed to distinguish AD from SVD. Conclusions: These results support the hypothesis that soluble Aß oligomers in the CSF of asymptomatic individuals may represent etiological biomarkers for AD. The ability of CSFAß oligomers to identify individuals who are at risk for developing AD warrants further investigation.