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P2‐102: Optimized ROI measures of FDG—PET improve characterization of early cognitive impairment and are comparable to PIB—PET
Author(s) -
Lowe Val,
Weigand Stephen,
Jack Clifford,
Kantarci Kejal,
Senjem Matthew,
Boeve Bradley,
Knopman David,
Petersen Ronald
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.991
Subject(s) - nuclear medicine , medicine , logistic regression , cognitive impairment , positron emission tomography , psychology , disease
33) and older controls (N 1⁄4 14), respectively. MTA and PA ratings were dichotomized into normal and abnormal, with a mean score of >1 being considered abnormal. Discriminatory power was assessed using area under the receiver operating characteristic curve (AUC). Logistic regression was used to combine MTA and PA ratings in predicting group membership. Results: MTA ratings were greater in AD and FTLD compared with controls (p < 0.0001). PA ratings were greater in AD compared with controls (p < 0.001) and FTLD (p 1⁄4 0.02). 32% of AD patients had PA in the absence of abnormal MTA, whereas 44% of the FTLD patients had MTA only (Figure). Combining MTA and PA ratings improved discrimination of AD from FTLD in the right hemisphere compared with MTA alone (AUC 1⁄4 0.72, p 1⁄4 0.02, Table). Whilst both EOAD and LOAD showed higher MTA scores compared with younger and older controls, respectively (p < 0.01), only EOAD showed greater PA scores (p < 0.0001). 33% of EOAD patients had PA only, whereas 46% of the LOAD patients had MTA only. Combining MTA and PA ratings improved the separation of EOAD from younger controls (AUC 1⁄4 0.89, p < 0.03, Table) compared to either scale alone. Conclusions: Marked PA was found in the absence of clear MTA in pathologicallyproven AD. Visual ratings of PA may be useful for distinguishing AD from FTLD and normal aging.