P2‐092: Amygdalar local structural differences in early‐ and late‐onset Alzheimer's patients

GSH and its oxidized product GSSG. Results: In parallel to increase in ROS, a twofold increase in 8-OHdG levels was observed in probable/possible sporadic AD subjects when compared with age matched controls. The present study also detected a significant increase in erythrocyte antioxidant SOD activity (p< 0.001) and GPx (p< 0.01) in probable/possible sporadic AD subjects. The current study also reveals a significant decrease in GSH (p < 0.001) and significant increase in the GSSG levels (p< 0.01) and a significant decrease in GSH/ GSSG molar ratio (p < 0.05) in probable/possible sporadic AD subjects.Conclusions: From the results of our findings the following conclusions can be made, although more studies are needed on a large sample with pre-symptomatic subjects or patients with other kinds of dementia, to determine the systemic oxidative stress is a key event to identify incipient AD, the present study suggest that these biomarkers have a clinical potential help to resolve this diagnostic challenge.