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P2‐092: Amygdalar local structural differences in early‐ and late‐onset Alzheimer's patients
Author(s) -
Cavedo Enrica,
Pievani Michela,
Boccardi Marina,
Galluzzi Samantha,
Bonetti Matteo,
Thompson Paul M.,
Frisoni Giovanni B
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.982
Subject(s) - amygdala , atrophy , early onset alzheimer's disease , anatomy , medicine , neuroscience , alzheimer's disease , psychology , disease
GSH and its oxidized product GSSG. Results: In parallel to increase in ROS, a twofold increase in 8-OHdG levels was observed in probable/possible sporadic AD subjects when compared with age matched controls. The present study also detected a significant increase in erythrocyte antioxidant SOD activity (p< 0.001) and GPx (p< 0.01) in probable/possible sporadic AD subjects. The current study also reveals a significant decrease in GSH (p < 0.001) and significant increase in the GSSG levels (p< 0.01) and a significant decrease in GSH/ GSSG molar ratio (p < 0.05) in probable/possible sporadic AD subjects.Conclusions: From the results of our findings the following conclusions can be made, although more studies are needed on a large sample with pre-symptomatic subjects or patients with other kinds of dementia, to determine the systemic oxidative stress is a key event to identify incipient AD, the present study suggest that these biomarkers have a clinical potential help to resolve this diagnostic challenge.