Premium
P2‐052: sAPP‐α and sApp‐β levels in Alzheimer's disease, Lewy body and Parkinson's disease dementia patients and their correlation with clinical diagnosis
Author(s) -
Mulugeta Ezra,
Skogseth Ragnhild,
Zetterberg Henrik,
Blennow Kaj,
Londos Elisabet,
Aarsland Dag
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.941
Subject(s) - dementia with lewy bodies , dementia , parkinson's disease , lewy body , neurochemical , medicine , gastroenterology , amyloid precursor protein , disease , correlation , alzheimer's disease , endocrinology , pathology , psychology , geometry , mathematics
and BBAR stage for Lewy body (LB) pathology (Saito Y et al 2004). Diagnosis of AD is based on NFT stage equal to or more than 4 and SP stage C (Murayama et al 2004). Diagnosis of DLB is based on the involvement of spinal cord, peripheral autonomic nervous system and CA2-3 of hippocampus with LB pathology, in addition to limbic and/ or neocortical involvement defined by the third DLB Consensus Guideline. Results: Significant correlation was present between the NFT or SP Stage and CSF tau, ptau, tau/Aß ratio or ptau/Aß ratio (p < 0.05). Significant inverse correlation was present between the LB Stage and 5-HIAA, and the NFT or SP Stage and Aß 1-42 (p < 0.05). Among the 73 cases examined, seven cases of AD, five cases of DLB and four cases of DLB+AD were included. HVA and tau in CSF was significantly higher in AD than in DLB as expected. In addition, 5-HIAA and tau/Aß ratio in AD was higher than that in DLB or DLB+AD (p < 0.05). Conclusions: This is the first report to show correlation with CSF tau, ptau and Aß, as well as 5-HIAA and HVA for Alzheimer and Lewy body pathology. This study highlighted usefulness of combined evaluation of AD and PD biomarkers for differential diagnosis of AD, DLB and their combination.