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P2‐049: Identification of proteins associated in three different populations of NTFS by mass spectrometry in cases of patients with AD
Author(s) -
Minjarez Benito,
Lopez José Luna,
Melgarejo Jorge Sosa,
Sánchez del Pino Manuel M.,
LunaArias Juan Pedro,
López Raúl Mena
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.938
Subject(s) - disease , dementia , identification (biology) , antibody , hippocampus , extracellular , medicine , neuroscience , pathology , biology , microbiology and biotechnology , immunology , botany
2.9 points (p1⁄4 0.034) less on the ADAS-Cog compared to the lowest tertile and therewas no association with theMMSE. Plasma ceramides did not predict decline on any test. Conclusions: These results suggest that high levels of SMs, but not ceramides, dose-dependently predict slower one-year decline on cognitive measures. Total plasma dihydrosphingomyelin appears to be a better predictor for cognitive progression and could provide a new treatment target.