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Dementia and Alzheimer's disease: A new direction. The 2010 Jay L. Foster Memorial Lecture
Author(s) -
Kuller Lewis H.,
Lopez Oscar L.
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.901
Subject(s) - dementia , apolipoprotein e , neuroscience , disease , alzheimer's disease , medicine , neuroimaging , positron emission tomography , vascular dementia , etiology , psychology , gerontology , psychiatry , pathology , bioinformatics , biology
Background The modern era of Alzheimer's disease (AD) research began in the early 1980s with the establishment of AD research centers and expanded research programs at the National Institute on Aging. Methods Over the past 30 years, there has been success in defining criteria for AD and dementia, association of important genetic disorders related to premature dementia in families, the association of apolipoprotein‐E 4 , and measurement of incidence and prevalence and selected risk factors. However, prevention and treatment have been elusive. Results The development of new technologies, especially magnetic resonance imaging, positron emission tomography to measure amyloid in vivo in the brain and glucose metabolism, cerebrospinal fluid examination, better genetic markers, large‐scale longitudinal epidemiology studies, and preventive clinical trials has rapidly begun a new era of research that offers opportunities to better understand etiology, that is, determinants of amyloid biology in the brain, neurofibrillary tangles, synaptic loss, and dementia. Conclusions There are three major hypotheses related to dementia: amyloid deposition and secondary synaptic loss as a unique disease, vascular injury, and “aging.” New research must be hypothesis‐driven and lead to testable approaches for treatment and prevention.