Premium
O2‐07‐05: Cerebral artery atherosclerosis is associated with Vascular Dementia, but not with Alzheimer's Disease: A population‐based postmortem series
Author(s) -
Suemoto Claudia,
Grinberg Lea,
Ferretti Renata,
Farfel Jose,
Leite Renata,
Oliveira Katia,
Tampellini Edilaine,
Alho Ana,
JacobFilho Wilson,
Nitrini Ricardo,
Pasqualucci Carlos
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.885
Subject(s) - atheroma , medicine , dementia , confounding , vascular dementia , stenosis , cardiology , population , risk factor , cerebral arteries , vascular disease , pathology , disease , environmental health
independently increased the odds of dementia in both the old andoldest old (all p-values<0.001). There was no difference in the relationship of AD or mixed pathologies to dementia in the oldest old compared to the younger old (p>0.2 for all interactions). Conclusions: The frequency of mixed pathologies increase with age. AD pathology, LB and infarcts all individually and in combination increase the odds of dementia in both younger and older elders. AD pathology has the same effect on clinical dementia in the old and oldest old when accounting for other pathologies.