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O2‐07‐03: Alzheimer's disease from a pathological point of view and what neurologists can learn from it
Author(s) -
Murray Melissa,
GraffRadford Neill,
Dickson Dennis
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.883
Subject(s) - atrophy , hippocampus , subiculum , pathology , temporal lobe , alzheimer's disease , pathological , medicine , hippocampal formation , dementia , neurofibrillary tangle , neuropathology , psychology , disease , neuroscience , senile plaques , dentate gyrus , epilepsy
association between baseline cognitive performance and NFT counts. In contrast, change in cognition was not a mediator of the association between baseline cognition and NP counts. Conclusions: The mediation effect of cognitive change in the NFT model effectively dates tangle development within the period of cognitive surveillance. The lack of a mediation effect in our NP model suggests that NP were deposited before the period of cognitive surveillance had begun. Thus, our analysis is consistent with an amyloid cascade model of early neocortical NP formation followed by NFT formation during 10 years of cognitive surveillance. This represents a methodological advance. Both the temporal period of observation and the spatial distribution of AD lesions can be constrained to more precisely define the sequence of events that characterize the AD process. We can model pathologies that cannot currently be imaged and in more representative population-based samples. It should also be feasible to explore the temporal and spatial progression of cross-sectional imaging data when suitable longitudinal clinical data are available.